Current Biology

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

Author: Guillaume Combes, Helena Barysz, Chantal Garand, John Maciejowski, Prasad V. Jallepalli, Sabine Elowe.

In Brief

Combes et al. demonstrate that autophosphorylation by the spindle checkpoint kinase Mps1 at its N-terminal extension relieves catalytic autoinhibition and is required for optimal checkpoint activity. This occurs independently of the role of the N-terminal extension in

kinetochore binding, suggesting multiple roles for this region during mitosis.

DOI: 10.1016/j.cub.2018.02.002

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