Trends in Biochemical Sciences

The spindle checkpoint proteins BUB1 and BUBR1: (SLiM)ming down to the basics

Author: Sabine Elowe, and Victor M. Bolanos-Garcia.

Budding uninhibited by benzimidazole 1 (BUB1) and budding uninhibited by

benzimidazole 1-related 1 (BUBR1) are multidomain paralogs with key roles in

chromosome alignment during mitosis and the spindle assembly checkpoint

(SAC), an evolutionarily conserved signaling pathway that monitors errors in

chromosome segregation during cell division in eukaryotes. Although BUB1

and BUBR1 share a similar domain organization and short linear interaction motifs (SLiMs), they control distinct aspects of chromosome congression and the

SAC. Here we discuss the roles of BUB1 and BUBR1 SLiMs in mitosis and complement this with additional insights gleamed from studying their evolution. We

show that BUB1 and BUBR1 SLiMs form highly specific interactions that are carefully

orchestrated in space and time and contend that they define BUB1 and

BUBR1 as organizing hubs that drive SAC signaling and ensure genome stability.

DOI: 10.1016/j.tibs.2022.01.004

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